Pentobarbital will decrease the level or effect of prednisone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Older adults or those with chronic medical conditions may experience depression, confusion, or excitement after taking the drug. pentobarbital will decrease the level or effect of atogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. https://monobookmarks.com/story20209086/i-pentobarbital-icp-diaries