Pentobarbital will decrease the level or effect of aprepitant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. pentobarbital will decrease the level or effect of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. pentobarbital will decrease the level or effect of exemestane by affecting hepatic/intestinal enz... https://hubwebsites.com/story21703903/the-ultimate-guide-to-pentobarbital-de-sodium