There exists a launch of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors during the dorsal horn to reduce afferent ache transmission and develop analgesia. Hence, medicine like clonidine that focus on alpha-2 receptors can impact the transmission of ache. Clonidine is distributed in breast milk; https://www.proleviate.com/post/the-new-pain-killer-conolidine